The Spectrum of Interstitial Lung Disease Associated With Autoimmune Diseases: Data of a 3.6-Year Prospective Study From a Referral Center of Interstitial Lung Disease and Lung Transplantation
| Autor: | Diana Prieto-Peña, David Iturbe-Fernández, Monica Calderón-Goercke, Víctor Manuel Mora Cuesta, Sara Remuzgo-Martínez, Alfonso Corrales, Sonia Fernández-Rozas, Belén Atienza-Mateo, Gerardo Blanco Rodríguez, Miguel A. González-Gay, José Javier Gómez-Román, José M. Cifrián |
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| Přispěvatelé: | Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Interstitial Pneumonia With Autoimmune Features Anti-nuclear antibody medicine.medical_treatment lcsh:Medicine behavioral disciplines and activities Interstitial Lung Disease Article Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Lung transplantation Prospective cohort study Connective Tissue Diseases 030203 arthritis & rheumatology Autoimmune disease business.industry lcsh:R Interstitial lung disease Autoantibody General Medicine respiratory system medicine.disease respiratory tract diseases body regions 030228 respiratory system Rheumatoid arthritis Rheumatic Autoimmune Diseases business |
| Zdroj: | J Clin Med 2020 May 26;9(6):E1606 Journal of Clinical Medicine Volume 9 Issue 6 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Journal of Clinical Medicine, Vol 9, Iss 1606, p 1606 (2020) |
| Popis: | Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed. This research received no external funding. SR-M is supported by funds of the RETICS Program (RD16/0012/0009) (Instituto de Salud Carlos III, co-funded by the European Regional Development Fund). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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