Serum Metabolomics Reveals That Gut Microbiome Perturbation Mediates Metabolic Disruption Induced by Arsenic Exposure in Mice
Autor: | Jiapeng Leng, Liang Chi, Pengcheng Tu, Jingchuan Xue, Hongyu Ru, Yunjia Lai, Kun Lu, Chih-Wei Liu |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Serum Metabolite Physiology chemistry.chemical_element Biology Biochemistry Mass Spectrometry Arsenic 03 medical and health sciences chemistry.chemical_compound Mice Metabolomics Metabolic Diseases Diabetes mellitus medicine Animals Carcinogen 030102 biochemistry & molecular biology Fatty acid metabolism General Chemistry Bacterial Infections medicine.disease Sphingolipid Gastrointestinal Microbiome Arsenic contamination of groundwater 030104 developmental biology chemistry Metabolome |
Zdroj: | Journal of proteome research. 18(3) |
ISSN: | 1535-3907 |
Popis: | Arsenic contamination in drinking water has been a worldwide health concern for decades. In addition to being a well-recognized carcinogen, arsenic exposure has also been linked to diabetes, neurological effects, and cardiovascular diseases. Recently, increasing evidence has indicated that gut microbiome is an important risk factor in modulating the development of diseases. We aim to investigate the role of gut microbiome perturbation in arsenic-induced diseases by coupling a mass-spectrometry-based metabolomics approach and an animal model with altered gut microbiome induced by bacterial infection. Serum metabolic profiling has revealed that gut microbiome perturbation and arsenic exposure induced the dramatic changes of numerous metabolite pathways, including fatty acid metabolism, phospholipids, sphingolipids, cholesterols, and tryptophan metabolism, which were not or were less disrupted when the gut microbiome stayed normal. In summary, this study suggests that gut microbiome perturbation can exacerbate or cause metabolic disorders induced by arsenic exposure. |
Databáze: | OpenAIRE |
Externí odkaz: |