Epstein-Barr Virus-associated Lymphoproliferative Disorder with Encephalitis Following Anti-thymocyte Globulin for Aplastic Anemia Resolved with Rituximab Therapy: A Case Report and Literature Review
| Autor: | Shinobu Takahara, Yutaro Kamiyama, Yuichi Yahagi, Kiyomi Mashima, Kazuhito Suzuki, Yoji Ogasawara, Katsuki Sugiyama, Hisashi Yamada, Atsushi Katsube, Keisuke Aiba, Sayaka Ohshima, Shingo Yano, Jiro Minami, Noriko Usui, Tomohito Machishima, Takaki Shimada, Hiroki Yokoyama, Takeshi Saito |
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| Rok vydání: | 2017 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human aplastic anemia encephalitis Lymphoproliferative disorders Case Report medicine.disease_cause Virus Anti-thymocyte globulin 03 medical and health sciences 0302 clinical medicine rituximab hemic and lymphatic diseases Internal Medicine medicine Humans Epstein-Barr virus Aplastic anemia Antilymphocyte Serum business.industry Anemia Aplastic General Medicine Middle Aged medicine.disease Epstein–Barr virus Lymphoproliferative Disorders Transplantation 030220 oncology & carcinogenesis Immunology Rituximab Female business lymphoproliferative disorder Encephalitis 030215 immunology medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. A 55-year-old woman with AA following ATG developed refractory fever and was diagnosed with EBV-LPD. She was successfully treated with weekly rituximab monotherapy; however, she developed EBV encephalitis. She was admitted to the intensive care unit and finally recovered from unconsciousness. EBV-LPD should be considered after ATG for AA when symptoms appear. Because EBV-LPD following ATG for AA can rapidly progress, weekly monitoring of EBV-DNA and early intervention may be necessary. |
| Databáze: | OpenAIRE |
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