Mn[III] uroporphyrin I: A novel metalloporphyrin contrast agent for magnetic resonance imaging
| Autor: | Solomon Batnitzky, Bruce F. Kimler, John H. McMillan, Glendon G. Cox, Jay S. Spicer |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Metalloporphyrins MRI contrast agent media_common.quotation_subject Biomedical Engineering Biophysics Femoral vein Brain tumor Contrast Media Autopsy Precontrast Drug Stability medicine Animals Contrast (vision) Radiology Nuclear Medicine and imaging media_common Manganese Mn(III) uroporphyrin I medicine.diagnostic_test Brain Neoplasms business.industry Magnetic resonance imaging Glioma Image Enhancement medicine.disease Magnetic Resonance Imaging Rats Inbred F344 Rats Spectrophotometry business Nuclear medicine |
| Zdroj: | Magnetic Resonance Imaging. 9:553-558 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/0730-725x(91)90042-k |
| Popis: | We have used an intracranial 9L rat brain tumor model to determine whether a novel metalloporphyrin, Mn[III] uroporphyrin I (MnUROP-I), could function as an intravenous MRI contrast agent for brain tumors. In several experiments, 24 male Fischer 344 rats were inoculated intracranially with 9L brain tumor cells. On day 15 postinoculation, animals were anesthetized and the femoral vein exposed. Prior to the intravenous injection of the contrast agent, a precontrast scan (1 Tesla in a standard head coil) was performed. Thirty min after injection of the contrast agent, a postcontrast scan was performed. Although there was only a suggestion of abnormality on the precontrast scans, the presence of tumor was visibly enhanced in the postcontrast scans. In 3 animals scanned at 24 hr postinjection, persistent tumor enhancement was demonstrated. Measured tumor sizes on the MRI scans were consistent with sizes measured at autopsy and histologically. These results demonstrate that MnUROP-I is an effective MRI contrast agent for the detection of an intracranial brain tumor in the rat model. |
| Databáze: | OpenAIRE |
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