Synthesis of certain pyrrole derivatives as antimicrobial agents
| Autor: | Mosaad S. Mohamed, Rania H. Abd El-Hameed, Ramdan Ahmed El-Domany |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pyrimidine
Gram-positive bacteria Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria chemistry.chemical_compound Structure-Activity Relationship Anti-Infective Agents Benzoin Gram-Negative Bacteria Organic chemistry Structure–activity relationship Pyrroles Pyrrole Malononitrile Pharmacology Antiinfective agent biology Molecular Structure Fungi General Medicine biology.organism_classification Antimicrobial Pyrimidines chemistry Drug Design |
| Zdroj: | Acta pharmaceutica (Zagreb, Croatia). 59(2) |
| ISSN: | 1330-0075 |
| Popis: | Synthesis of certain pyrrole derivatives as antimicro-bial agentsIn an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis andin vitromicrobiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivatives (2a-dto5a-d) and pyrrolo[2,3-d]pyrimidines (6a-dto10a, d) were synthesized. Thein vitroantimicrobial testing of the synthesized compounds was carried out against Gram-positive, Gram-negative bacteria and fungi. Some of the prepared compounds, [2-amino-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrole-3-carbonitriles (1b), 2-amino-3-carbamoyl-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrroles (2b),N-(3-cyano-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamides (3b),N-(3-cyano-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamides (3c), 2-amino-1-(4-methoxyphenyl)-4,5-diphenyl-3-tetrazolo-1H-pyrroles (5d),7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo [2,3-d]pyrimidin-4(3H)-ones (7d), 7-(3-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-thione (9b) andN-(7-(2-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d] pyrimidine)-N-aryl amines (10a)] showed potent antimicrobial activity. |
| Databáze: | OpenAIRE |
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