Association of obstructive sleep apnea severity with the composition of the upper airway microbiome
| Autor: | Hana Yi, Seung No Hong, Chae-Seo Rhee, Min-Gyung Baek, Kang Jin Kim, Chol Shin, Chul Hee Lee, Seung Hoon Lee, Dong-Young Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Sleep Apnea Obstructive business.industry Microbiota Polysomnography Middle Aged medicine.disease Bioinformatics Scientific Investigations respiratory tract diseases Obstructive sleep apnea Pathogenesis Cohort Studies Neurology Underlying disease RNA Ribosomal 16S medicine Humans Female Neurology (clinical) Microbiome Airway business Aged |
| Zdroj: | J Clin Sleep Med |
| Popis: | STUDY OBJECTIVES: Although the airway mucosal system plays a pivotal role in the pathogenesis of obstructive sleep apnea (OSA), the underlying disease mechanism remains unclear. The microbiome greatly impacts human health and disease, particularly in the mucosa, where it can have direct interactions. In this study, we aimed to analyze the microbiome composition in the upper airway mucosa of individuals with and without OSA to identify potential disease severity–related microbial signatures. METHODS: This population-based cohort study involved 92 participants (mean age = 62.7 ± 5.8 years; male-to-female ratio = 0.74) who underwent a physical examination and sleep study. Upper airway swab samples were collected from the nasopharyngeal mucosa to evaluate the microbiome based on 16S rRNA gene pyrosequencing. The relationship between microbiome composition and sleep parameters was explored through bioinformatics analysis. RESULTS: The average apnea-hypopnea index was 7.75 ± 6.5 events/h. Proteobacteria, Firmicutes, and Actinobacteria were the predominant phyla in the nasopharyngeal microbiota in all participants. Simpson diversity indexes were higher in patients with OSA (0.6435 ± 0.2827) than in the control patients (0.6095 ± 0.2683); however, the difference was not significant (P = .1155). Specific anaerobes negatively correlated with the lowest oxygen saturation level during sleep (sum of powered score (1) = –117.47; P = .0052). CONCLUSIONS: The upper airway microbiome of older patients with mild-moderate OSA exhibited minor differences in composition compared with that of individuals without OSA, possibly owing to environmental changes in the upper airway mucosa resulting from recurrent airway obstruction and intermittent hypoxia in patients with OSA. CITATION: Hong S-N, Kim KJ, Baek M-G, et al. Association of obstructive sleep apnea severity with the composition of the upper airway microbiome. J Clin Sleep Med. 2022;18(2):505–515. |
| Databáze: | OpenAIRE |
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