Early Impact of Pulmonary Fractionated Stereotactic Body Radiotherapy on Quality of Life:Benefit for Patients With Low Initial Scores (STRIPE Trial)
| Autor: | Felix Momm, Sonja Adebahr, Gerhild Becker, V. Duncker-Rohr, Eleni Gkika, Ursula Nestle, Nele Schräder, Jan Gaertner, Tanja Schimek-Jasch, Marlene Hechtner, Anca-Ligia Grosu, Klaus Kaier |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Health Status Radiosurgery Emotional function 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires Internal medicine medicine Humans Prospective Studies Aged Lung business.industry Cancer Prognosis medicine.disease humanities Karnofsky index 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Charlson comorbidity index Quality of Life Female Dose Fractionation Radiation business Stereotactic body radiotherapy Follow-Up Studies |
| Zdroj: | Journal of Thoracic Oncology. 14:408-419 |
| ISSN: | 1556-0864 |
| Popis: | Introduction Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering fractionated stereotactic body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL. Methods One hundred patients with pulmonary lesions were treated with SBRT from February 2011 to December 2014 within the prospective, monocenter, phase II STRIPE trial. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core module (EORTC QLQ-C30) and the QLQ-LC13 lung cancer-specific questionnaire were used to evaluate QoL before, 2 and 7 weeks after SBRT, then every 3 months for 2 years. We report on the analysis of early changes from baseline to 7-week follow-up exam. Impact of patient- and treatment-related factors on the change in QoL was analyzed. Results QoL was assessed in 97 patients; compliance was 92% and 85% at baseline and 7 weeks after SBRT, respectively. No clinically relevant changes greater than or equal to 10 in the QoL/global health status (GHS), function scores and inquired symptoms were observed. Patients with baseline QoL below the median showed clinically relevant improvement in QoL/GHS (Δ16.7 ± 25.3, p = 0.003), emotional function (Δ14.4 ± 25.4, p = 0.013), and fatigue (Δ -10.1 ± 26.5, p = 0.089) in contrast to patients with high initial scores. No changes were observed in the dichotomized subgroups of initial Karnofsky index, Charlson Comorbidity Index, age, diagnosis, and tumor localization. Conclusions In short-term follow-up, QoL is well maintained after pulmonary SBRT. Especially patients with low initial QoL/GHS scores show benefit from SBRT with respect to QoL. |
| Databáze: | OpenAIRE |
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