Tissue distribution metabolism and excretion of 2,2?,4,4?, 5-pentachlorodiphenyl ether in the rat
| Autor: | E. Komsta, F. M. Benoit, I Chu, D. C. Villeneuve, D. Murdoch |
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| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Chemical Phenomena Health Toxicology and Mutagenesis Urine Toxicology Mass Spectrometry Excretion Feces Pharmacokinetics Oral administration Internal medicine medicine Animals Toxicokinetics Tissue Distribution Carbon Radioisotopes Kidney Chemistry Rats Inbred Strains General Medicine Metabolism Polychlorinated Biphenyls Rats medicine.anatomical_structure Endocrinology Toxicity Environmental Pollutants Ethers |
| Zdroj: | Archives of Toxicology. 62:258-262 |
| ISSN: | 1432-0738 0340-5761 |
| DOI: | 10.1007/bf00332484 |
| Popis: | The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in the tissues was due to unchanged PCDE. Decay of PCDE in the blood was fitted to a four-compartment pharmacokinetic model, and the last compartment had a half-life of 5.8 days. A total of 55% and 1.3% of an orally administered dose was excreted in feces and urine, respectively, in 7 days. More than 64% of the fecal radioactivity was due to unchanged PCDE, while hydroxylated PCDE accounted for 23%. |
| Databáze: | OpenAIRE |
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