Red Marrow Absorbed Dose Calculation in Thyroid Cancer Patient Using a Simplified Excel Spreadsheet
| Autor: | Putthiporn Charoenphun, Rangsee Songprakhon, Krisanat Chuamsaamarkkee, Krisana Roysri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Wilcoxon signed-rank test image-based dosimetry red marrow absorbed dose lcsh:R895-920 lcsh:Medicine 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Software Dosimetry Medicine Radiology Nuclear Medicine and imaging Internal dosimetry Medical physics internal dosimetry Commercial software lcsh:R5-920 business.industry lcsh:R radioiodine therapy 030220 oncology & carcinogenesis Absorbed dose Dose assessment Red Marrow Original Article business lcsh:Medicine (General) |
| Zdroj: | Molecular Imaging and Radionuclide Therapy, Vol 29, Iss 3, Pp 124-131 (2020) Molecular Imaging and Radionuclide Therapy |
| ISSN: | 2147-1959 2146-1414 |
| Popis: | Objectives: Absorbed dose to red marrow (Drm) can be calculated using blood dosimetry. However, this method is laborious and invasive. Therefore, image-based dosimetry is the method of choice. Nonetheless, the commercial software is expensive. The goal of this work was to develop a simplified excel spreadsheet for image-based radioiodine red marrow dosimetry. Methods: The serial whole-body images (acquired at 2nd, 6th, 24th, 48th, and 72th hours) of 29 patients from the routine pretherapeutic dosimetry protocol were retrospectively reanalyzed. The commercial OLINDA/EXM image-based dosimetry software was used to calculate the whole-body time-integrated activity coefficient (TIACWB) and Drm [in terms of absorbed dose coefficient (drm)]. For the simplified excel spreadsheet, the whole-body count was obtained from the vendor-supplied software. Then, the TIACWB was computed by a fitting time-activity curve using an Excel function. S factor was taken from other publications and scaled according to the patient-specific mass. A comparison of the TIACWB and drm from both methods was done using a non-inferiority test using a paired t-test or the Wilcoxon signed-rank test. Results: The TIACWB showed no significant difference between both methods (p=0.243). The calculated Drm from a simplified Excel spreadsheet was assumed to be statistically non-inferior to the commercial OLINDA/EXM image-based dosimetry software with the non-inferiority margin of 0.02 (p |
| Databáze: | OpenAIRE |
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