Lack of association of some chemokine system polymorphisms with the risks of death and hepatocellular carcinoma occurrence in patients with alcoholic cirrhosis: a prospective study
| Autor: | Jean-Claude Trinchet, Chantal Simon, Nathalie Barget, Nathalie Charnaux, Angela Sutton, Michel Beaugrand, Pierre Rufat, Pierre Nahon, Charles Faisant, Liliane Gattegno |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Alcoholic liver disease CCR2 Carcinoma Hepatocellular Alcohol Drinking Genotype Receptors CCR5 Receptors CCR2 Temperance CCL5 Liver disease Chemokine receptor Liver Cirrhosis Alcoholic medicine Humans Genetic Predisposition to Disease Chemokine CCL5 Chemokine CCL2 Aged Polymorphism Genetic Hepatology business.industry Liver Neoplasms Gastroenterology Hepatitis C Middle Aged medicine.disease Prognosis Chemokine CXCL12 Hepatocellular carcinoma Immunology Female Receptors Chemokine Chemokines business CC chemokine receptors Epidemiologic Methods Chemokines CXC |
| Zdroj: | European journal of gastroenterologyhepatology. 19(5) |
| ISSN: | 0954-691X |
| Popis: | BACKGROUND: Polymorphisms in genes encoding for the chemokines stromal cell-derived factor-1 (SDF-1)/CXCL12, monocyte chemotactic protein-1 (MCP-1)/CCL2, or for the chemokine receptors, CC chemokine receptor 5 (CCR5) or CC chemokine receptor 2 (CCR2) have been associated with the progression of hepatitis C virus-related liver injury and with various cancer development. Their influence on the prognosis of alcoholic liver disease is unknown. PATIENTS AND METHODS: SDF-1 3'A, MCP-1(-2518), CCR5-Delta32 and CCR2-64I polymorphisms, SDF-1alpha, regulated upon activation normal T cells expressed and secreted (RANTES)/CCL5 and MCP-1 sera levels were determined in 222 alcoholic patients, included at the time of cirrhosis diagnosis and prospectively followed up. RESULTS: Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. Mean time of follow-up of the cohort was 62.9+/-43.2 months. One hundred and forty-seven out of 222 (66.3%) patients were alive at the end of the study. The occurrence of death (75/222; 33.7%) or hepatocellular carcinoma (67/222; 30.1%) during follow-up was similar among carriers and noncarriers of each polymorphism. No association between the carriage of mutated alleles and chemokine sera levels was found: CCR5-Delta32/RANTES, SDF-1 3'A/SDF-1alpha and CCR2-64I or MCP-1(-2518)/MCP-1. Baseline RANTES, SDF-1alpha and MCP-1 sera levels were associated neither with the risk of death nor with the risk of hepatocellular carcinoma. CONCLUSIONS: The present study suggests the lack of association of SDF-1 3'A, MCP-1(-2518), CCR5-Delta32 and CCR2-64I polymorphisms with death and hepatocellular carcinoma occurrence in cirrhotic alcoholic patients. |
| Databáze: | OpenAIRE |
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