The potential use of urinary hCG measurements in the management of pregnancies of unknown location
| Autor: | Maya Al-Memar, Catriona Stalder, Yazan Abdallah, Richard J. Harvey, Dirk Timmerman, Tom Bourne, Rosemary A. Fisher, Shabnam Bobdiwala |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty Urology Urine Chorionic Gonadotropin Human chorionic gonadotropin chemistry.chemical_compound Serum hcg Pregnancy medicine Humans Prospective Studies Prospective cohort study Creatinine Ectopic pregnancy business.industry Pregnancy Outcome Obstetrics and Gynecology General Medicine medicine.disease Urinary hCG Pregnancy Ectopic Reproductive Medicine chemistry Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human Fertility. 25:256-263 |
| ISSN: | 1742-8149 1464-7273 |
| DOI: | 10.1080/14647273.2020.1777590 |
| Popis: | Multiple measurements of serum human chorionic gonadotropin (hCG) are used to predict the final pregnancy outcome for women with a pregnancy of unknown location (PUL) and monitor the management of ectopic pregnancy (EP). Urine-based testing would be more convenient and economical. This prospective cohort study involving 80 women assessed the degree of correlation between serum and urine hCG levels and whether urine hCG levels have the potential to impact clinical decision making in the management of women with a PUL. Paired urine and serum hCG measurements differed quite widely but were well correlated and the degree of correlation improved after creatinine correction. Although serial serum hCG measurements appear to be better for the overall prediction of pregnancy outcome in PUL (AUC 0.77-0.94 compared to corrected urine AUC 0.69-0.84), serial urine hCG measurements may have a role in identifying subtypes of low-risk PUL (AUC 0.83-0.84). |
| Databáze: | OpenAIRE |
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