Endemic goiter in Greece: salivary iodide clearance in goitrous and nongoitrous persons
| Autor: | C. N. Tassopoulos, D. A. Koutras, S. Marketos |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Adult
Atropine Male medicine.medical_specialty Saliva Goiter Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Iodide Thyroid Gland Biochemistry Hyperthyroidism Salivary Glands Indirect evidence Iodine Radioisotopes Endocrinology Hypothyroidism Internal medicine parasitic diseases Blood plasma medicine Humans chemistry.chemical_classification Greece business.industry Biochemistry (medical) Significant difference Thyroid Pilocarpine Iodides Middle Aged medicine.disease Iodine deficiency medicine.anatomical_structure chemistry Female business Salivation |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 27(6) |
| ISSN: | 0021-972X |
| Popis: | The mixed salivary iodide clearance rate (Sal. 131I CI.), the salivary flow and the saliva/plasma (S/P) ratio of iodide were measured in 30 patients with endemic goiter, 17 nongoitrous inhabitants of the endemic areas, 50 “normal” persons from non-endemic areas, 20 hyper- and 9 hypothyroid patients. A significant inverse relation between salivary flow and S/P ratio was found. The nongoitrous persons from the endemic areas had significantly higher salivary flow and Sal. 131I Cl. values than the patients with endemic goiter or the normal controls. There was no significant difference in the S/P ratio. It is suggested that the finding of a higher Sal. 131I CI. (or, expressed otherwise, of a similar S/P ratio in spite of a higher salivary flow) provides evidence for a more efficient salivary iodide trap in the nongoitrous inhabitants of the endemic areas. In view of the similarities between the salivary and the thyroid glands, this provides indirect evidence for the hypothesis that the nongoitrous per... |
| Databáze: | OpenAIRE |
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