Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones
| Autor: | Saeed Emami, Abbas Shafiee, Negar Mohammadhosseini, Mohammad Ali Faramarzi, Bahram Letafat, Alireza Foroumadi, Nasrin Samadi |
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| Rok vydání: | 2007 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared medicine.drug_class Stereochemistry Substituent General Chemistry General Medicine Microbial Sensitivity Tests Quinolones Quinolone Oxime Medicinal chemistry Anti-Bacterial Agents Ciprofloxacin Piperazine chemistry.chemical_compound chemistry Drug Discovery medicine Moiety Antibacterial activity Norfloxacin medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 55(6) |
| ISSN: | 0009-2363 |
| Popis: | As a part of continuing search for potential antibacterial agents in the quinolones field, we have synthesized novel quinolone agents bearing N-[2-(thiophen-3-yl)ethyl] piperazinyl moiety in the 7-position of the quinolone ring. In vitro antibacterial evaluation of the target compounds showed that N-[2-(thiophen-3-yl)ethyl] group attached to piperazine ring served as promising C-7 substituent for piperazinyl quinolone antibacterials. Among these derivatives, ciprofloxacin analogues, containing N-[2-(thiophen-3-yl)-2-hydroxyiminoethyl] or N-[2-(thiophen-3-yl)-2-methoxyiminoethyl] residue provided a high inhibition against all the tested Gram-positive organisms including methicillin-resistant Staphylococcus aureus comparable or superior with respect to the reference drugs norfloxacin and ciprofloxacin. |
| Databáze: | OpenAIRE |
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