The effects of tirofiban infusion on clinical and angiographic outcomes of patients with STEMI undergoing primary PCI
| Autor: | Alper Özkan, Muhsin Turkmen, Nihal Özdemir, Mehmet Mustafa Can, Cevat Kirma, Hacer Ct. Demircan, Ali Metin Esen, İbrahim Akın İzgi, Nursen Keles, Ibrahim Halil Tanboga, Cihangir Kaymaz, Fatih Koca |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty tirofiban medicine.medical_treatment Coronary Angiography Drug Administration Schedule Bolus (medicine) Fibrinolytic Agents Internal medicine medicine Humans angiography Myocardial infarction cardiovascular diseases Infusions Intravenous Letter to the Editor Aged Retrospective Studies Original Investigation Aspirin business.industry percutaneous coronary intervention Percutaneous coronary intervention Tirofiban Middle Aged medicine.disease Clopidogrel surgical procedures operative myocardial infarction Conventional PCI Cardiology treatment outcome Tyrosine Female Cardiology and Cardiovascular Medicine business TIMI medicine.drug |
| Zdroj: | Anatolian Journal of Cardiology |
| ISSN: | 2149-2271 2149-2263 |
| Popis: | Objective: The present study was designed to determine the effects of tirofiban (Tiro) infusion on angiographic measures, ST-segment resolution, and clinical outcomes in patients with STEMI undergoing PCI. Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI), while the most effective timing of administration is still under investigation. Methods: A total of 1242 patients (83.0% males, mean (standard deviation; SD) age: 54.7 (10.9) years) with STEMI who underwent primary PCI were included in this retrospective non-randomized study in four groups, composed of no tirofiban infusion [Tiro (-); n=248], tirofiban infusion before PCI (pre-Tiro; n=720), tirofiban infusion during PCI (peri-Tiro; n=50), and tirofiban infusion after PCI (post-Tiro; n=224). In all Tiro (+) patients, bolus administration of Tiro (10 pg/kg) was followed by infusion (0.15 pg/kg/min) for a mean (SD) duration of 22.4±6.8 hours. Results: The pre-PCI Tiro group was associated with the highest percentage of patients with TIMI 3 flow (99.4%; p75% ST-segment resolution (78.1%; p |
| Databáze: | OpenAIRE |
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