Adipose tissue versus stem cell-derived small extracellular vesicles to enhance the healing of acute burns
| Autor: | Elahe Mahdipour, Jalil Rohani Ivari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Embryology Burn injury Biomedical Engineering Adipose tissue Extracellular vesicles 03 medical and health sciences Extracellular Vesicles Mice 0302 clinical medicine Medicine Animals business.industry Stem Cells Mesenchymal stem cell Granulation tissue Mesenchymal Stem Cells Cell biology 030104 developmental biology medicine.anatomical_structure Adipose Tissue 030220 oncology & carcinogenesis Wound closure Stem cell business Burns |
| Zdroj: | Regenerative medicine. 16(7) |
| ISSN: | 1746-076X |
| Popis: | Aim: Proper healing of extensive burns remains a healthcare challenge. In the present study, we proposed a distinct therapeutic application of adipose tissue and small extracellular vesicles isolated from human menstrual blood-derived mesenchymal stem cells (MenSC) small extracellular vesicles (sEVs) to enhance the repair of third-degree burn injury. Materials & methods: Mouse model of third-degree burn was used. Adipose tissue in the form of nano-fat (NF) and MenSC-sEVs was injected subcutaneously at the site of injuries. Results: NF and sEVs were capable of enhancing wound closure and increasing neoangiogenesis. NF was also effective in accelerating the formation of granulation tissue and boosting the thickness of the new epithelial layer. Conclusion: This study demonstrates the effectiveness of NF and MenSC-sEVs as promising therapeutic approaches to facilitate the repair of skin burns. |
| Databáze: | OpenAIRE |
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