AANG Prevents Smad3-dependent Diabetic Nephropathy by Restoring Pancreatic β-Cell Development in db/db Mice
| Autor: | Jeff Yat-Fai Chung, Patrick Ming-Kuen Tang, Max Kam-Kwan Chan, Li Wang, Xiao-Ru Huang, Ka-Fai To, Ronald CW Ma, Hui-Yao Lan |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Blood Glucose
Glycated Hemoglobin Insulins NF-kappa B Cell Biology Applied Microbiology and Biotechnology Fibrosis Transforming Growth Factor beta1 Mice Diabetes Mellitus Type 2 Animals Diabetic Nephropathies Smad3 Protein Molecular Biology Ecology Evolution Behavior and Systematics Developmental Biology |
| Zdroj: | International journal of biological sciences. 18(14) |
| ISSN: | 1449-2288 |
| Popis: | Diabetic nephropathy (DN) is a major cause of end-stage kidney disease, where TGF-β1/Smad signaling plays an important role in the disease progression. Our previous studies demonstrated a combination of Traditional Chinese Medicine derived Smad7 agonist Asiatic Acid (AA) and Smad3 inhibitor Naringenin (NG), AANG, effectively suppressed the progression of renal fibrosis |
| Databáze: | OpenAIRE |
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