Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis

Autor: Enea Bonci, Caterina Anania, Claudio Chiesa, Lucia Pacifico, Lucia Martina Silvestri, Paolo Versacci
Rok vydání: 2014
Předmět:
Genetics and Molecular Biology (all)
nonalcoholic fatty liver disease
Male
obesity
Immunology and Microbiology (all)
lcsh:Medicine
Comorbidity
Review Article
030204 cardiovascular system & hematology
Chronic liver disease
Biochemistry
Gastroenterology
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Risk Factors
Nonalcoholic fatty liver disease
80 and over
Child
Subclinical infection
Ultrasonography
Aged
80 and over
General Medicine
Middle Aged
3. Good health
Causality
Survival Rate
Cardiovascular Diseases
Child
Preschool
030211 gastroenterology & hepatology
Female
Adult
medicine.medical_specialty
Adolescent
subclinical atherosclerosis
metabolic syndrome
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Young Adult
Insulin resistance
Age Distribution
Internal medicine
medicine
Humans
Aged
Sex Distribution
Biochemistry
Genetics and Molecular Biology (all)
Risk factor
Preschool
General Immunology and Microbiology
business.industry
lcsh:R
nutritional and metabolic diseases
medicine.disease
Endocrinology
Arterial stiffness
Metabolic syndrome
business
Dyslipidemia
Zdroj: BioMed Research International
BioMed Research International (Online) 2015 (2015): Article ID 213737. doi:10.1155/2015/213737
info:cnr-pdr/source/autori:1 Bonci E, 2 Chiesa C, 3 Versacci P, 3 Anania C, 3 Silvestri L, 3 Pacifico L/titolo:Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis/doi:10.1155%2F2015%2F213737/rivista:BioMed Research International (Online)/anno:2015/pagina_da:Article ID 213737/pagina_a:/intervallo_pagine:Article ID 213737/volume:2015
BioMed Research International, Vol 2015 (2015)
ISSN: 2314-6141
DOI: 10.1155/2015/213737
Popis: In the last 20 years, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, primarily as a result of the epidemic of obesity. NAFLD is strongly associated with insulin resistance, glucose intolerance, and dyslipidemia and is currently regarded as the liver manifestation of the metabolic syndrome, a highly atherogenic condition even at a very early age. Patients with NAFLD including pediatric subjects have a higher prevalence of subclinical atherosclerosis, as shown by impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, which are independent of obesity and other established risk factors. More recent work has identified NAFLD as a risk factor not only for premature coronary heart disease and cardiovascular events, but also for early subclinical abnormalities in myocardial structure and function. Thus, we conducted a systematic review and meta-analysis to test the hypothesis that NAFLD is associated with evidence of subclinical cardiac structural and functional abnormalities.
Databáze: OpenAIRE
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