Postnatal exposure to finasteride causes different effects on the prostate of male and female gerbils
| Autor: | Carolina M. Bedolo, Vitória Alário dos Santos, Marilia Freitas Calmon, Rejane M. Góes, Juliana S. Maldarine, Bruno D. A. Sanches, Sebastião Roberto Taboga, Paula Rahal, Patricia S.L. Vilamaior, Maria Letícia Duarte Lima, Ágata Silva Cabral |
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| Přispěvatelé: | Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.drug_class Gerbil 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Prostate developmental exposure Internal medicine androgen receptor medicine female prostate Animals Testosterone business.industry gerbil Finasteride Cell Biology General Medicine Androgen finasteride Androgen receptor 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Receptors Androgen 030220 oncology & carcinogenesis Dihydrotestosterone Female branching morphogenesis Gerbillinae business medicine.drug Hormone |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:59:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The development and maintenance of prostate function depend on a fine balance between oestrogen and androgen levels. Finasteride inhibits 5α-reductase, which is responsible for the conversion of testosterone into its most active form, dihydrotestosterone. Enzymes that metabolize these hormones have a highly relevant role in both the normal prostate metabolism and in the occurrence of pathological conditions. There are few studies on the impact of finasteride on male prostate development and fewer studies on the female prostate and possible intersexual differences. Therefore, we treated male and female gerbils from 7 to 14 days in postnatal life with a high dose of finasteride (500 μg/kg/day); the prostate complexes were then removed and submitted to immunohistochemistry, immunofluorescence and three-dimensional reconstruction. In addition, hormonal serum dosages were administered. Treatment with finasteride resulted in an increased thickness of the periductal smooth musculature in the prostate of both male and female gerbils, such as well as a reduction in the thickness of developing prostate alveoli in both sexes. In addition, intersexual differences were observed as increased epithelial proliferation and decreases in the number of developing alveoli in females. Together, the data indicate that postnatal exposure to finasteride causes greater changes in the female gerbil prostate than in the male. Department of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), Bertrand RusseLl Av. Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo Laboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo Laboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo FAPESP: 2013/15939-0 FAPESP: 2016/16509-8 CNPq: 305840/2015-0 CNPq: 442630/2014-0 |
| Databáze: | OpenAIRE |
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