Osa patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears

Autor:	Annalisa Pace, Valeria Rossetti, Alessandro Milani, Giannicola Iannella, Salvatore Cocuzza, Antonino Maniaci, Danilo Alunni Fegatelli, Annarita Vestri, Antonio Greco, Marco De Vincentiis, Francesca Giovannetti, Rocco Plateroti, Giuseppe Magliulo
Rok vydání:	2022
Předmět:	Narrow Band Imaging Medicine (General) R5-920 General Medicine skin and connective tissue diseases Obstructive sleep apnea laryngopharyngeal reflux disease pepsin nervous system diseases respiratory tract diseases
Zdroj:	Bosnian Journal of Basic Medical Sciences (2022)
ISSN:	1840-4812 1512-8601
Popis:	Obstructive sleep apnoea (OSA) and laryngopharyngeal reflux disease (LPR) are two common diseases that lower patients' quality of life. OSA is defined by cyclic events of airflow obstruction that occur during sleep, while LPR is characterized by upper airway inflammatory signs and symptoms due to the return of gastroduodenal gaseous and liquid elements. pH-metry is the gold standard in LPR diagnosis, but considering its invasiveness among other negative traits, questionnaires that catalog symptoms and signs of the disease such as Reflux Symptoms Index (RSI) and Reflux Finding Score (RFS) are preferred. Moreover, LPR can be evaluated by testing the presence of pepsin in tears, and Narrow Band Imaging (NBI) has been introduced for the early diagnosis of larynx oncological disease. This paper aims to test whether LPR is more frequent in OSA patients than in control ones, performing a non-invasive protocol composed of RSI, RFS test (with light vs. NBI techniques), followed by pepsin detection in tears. 68 LPR patients were enrolled in the study (45 with OSA and 23 without OSA). A strong linear relationship between Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) was found, and patients who presented pepsin in tears had higher values of AHI and ODI in comparison to patients without it. Pathological RFS and NBI showed higher values of AHI and ODI in comparison to the control group. Furthermore, pathological RSI showed higher values of AHI and ODI in comparison to the control group. In conclusion, this diagnostic combined non-invasive protocol may be a good method to perform an early diagnosis of LPR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa137d1d49965e59bb3a857f3cf7dad6 https://doi.org/10.17305/bjbms.2021.6712 Zobrazit plný text záznamu