IMMUNOPHENOTYPING OF ACUTE LEUKAEMIAS : A CRITICAL ANALYSIS OF 35 CASES

Autor:	Harsh Kumar, R Ranga Rao, J R Bhardwaj, J S Panayach, Rajat Kumar, P Sivadas
Rok vydání:	2017
Předmět:	business.industry medicine.drug_class Original Phosphatase hemic and immune systems General Medicine Acute leukaemias Monoclonal antibody Case management medicine.disease Leukemia Immunophenotyping hemic and lymphatic diseases Cancer research Medicine Alkaline phosphatase Myeloid leukaemia business
Zdroj:	Medical journal, Armed Forces India. 51(3)
ISSN:	0377-1237
Popis:	Accurate classification of acute leukaemias is essential for proper case management. The utility of monoclonal antibodies in the diagnosis and classification of acute leukaemias is well established. This diagnostic utility relates primarily to two points : firstly the distinction between acute myeloid leukaemia and acute lymphoblastic leukaemia and secondly to subtypes of acute lymphoblastic leukaemia. Leukaemic cells were immunophenotyped using the alkaline phosphatase antialkaline phosphatase techniques. The monoclonal antibodies were very useful in distinguishing cases of acute myeloid leukaemia from acute lymphoblastic leukaemia. Cases of acute lymphoblastic leukaemia with CD10 positivity showed a better prognosis. T-cell acute lymphoblastic leukaemia was uncommon and was associated with unfavourable prognosis. The alkaline phosphatase antialkaline phosphatase technique served as a reliable and convenient method for immunophenotyping of leukaemias.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa11a1427268cac87aefd8954b8467c1 https://pubmed.ncbi.nlm.nih.gov/28769280 Zobrazit plný text záznamu Full Text from ScienceDirect