Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems
| Autor: | Xin Chun Huang, Yu Cheng Chen, Yun Ling Luo, Yung Chen Chang, You-Zung Hsieh, Hsin-Yun Hsu |
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| Rok vydání: | 2013 |
| Předmět: |
theranostics
Materials science lcsh:Biotechnology Human life Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanomaterials drug delivery systems lcsh:TP248.13-248.65 lcsh:TA401-492 medicine General Materials Science mesoporous silica nanoparticles Cancer Focus Articles Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Cancer treatment Chemical functionalization Drug delivery lcsh:Materials of engineering and construction. Mechanics of materials carbon-based nanomaterials Nanocarriers 0210 nano-technology |
| Zdroj: | Science and Technology of Advanced Materials Science and Technology of Advanced Materials, Vol 14, Iss 4, p 044407 (2013) |
| ISSN: | 1468-6996 |
| Popis: | The rapid development in nanomaterials has brought great opportunities to cancer theranostics, which aims to combine diagnostics and therapy for cancer treatment and thereby improve the healthcare of patients. In this review we focus on the recent progress of several cancer theranostic strategies using mesoporous silica nanoparticles and carbon-based nanomaterials. Silicon and carbon are both group IV elements; they have been the most abundant and significant non-metallic substances in human life. Their intrinsic physical/chemical properties are of critical importance in the fabrication of multifunctional drug delivery systems. Responsive nanocarriers constructed using these nanomaterials have been promising in cancer-specific theranostics during the past decade. In all cases, either a controlled texture or the chemical functionalization is coupled with adaptive properties, such as pH-, light-, redox- and magnetic field- triggered responses. Several studies in cells and mice models have implied their underlying therapeutic efficacy; however, detailed and long-term in vivo clinical evaluations are certainly required to make these bench-made materials compatible in real bedside circumstances. |
| Databáze: | OpenAIRE |
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