Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
| Autor: | Randal G, Ross, Ann, Olincy, Susan K, Mikulich, Allen D, Radant, Josette G, Harris, Merilyne, Waldo, Nina, Compagnon, Shari, Heinlein, Sherry, Leonard, Gary O, Zerbe, Lawrence, Adler, Robert, Freedman |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Aged 80 and over Male Risk Adolescent Endocrine and Autonomic Systems Cognitive Neuroscience General Neuroscience Experimental and Cognitive Psychology Middle Aged Pursuit Smooth Phenotype Neuropsychology and Physiological Psychology Psychotic Disorders Developmental Neuroscience Neurology Reference Values Saccades Schizophrenia Humans Female Genetic Predisposition to Disease Genetic Testing Biological Psychiatry Aged |
| Zdroj: | Psychophysiology. 39:809-819 |
| ISSN: | 1469-8986 0048-5772 |
| DOI: | 10.1111/1469-8986.3960809 |
| Popis: | Abnormalities during a smooth pursuit eye movement task (SPEM) are common in schizophrenic patients and their relatives. This study assessed various components of SPEM performance in first-degree unaffected relatives of schizophrenic patients. One hundred individuals with schizophrenia, 137 unaffected first-degree relatives, and 69 normal controls completed a 16.7 degrees/s SPEM task. Smooth pursuit gain, catch-up saccades (CUS), large anticipatory saccades, and leading saccades (LS) were identified. Groups were compared with parametric and admixture analyses. Schizophrenic patients performed more poorly than unaffected relatives and normals on gain, CUS, and LS. Unaffected relatives were more frequently impaired than normals only on gain and LS. Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia. |
| Databáze: | OpenAIRE |
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