The role of ADRB2 gene polymorphisms in malignancies
| Autor: | Yaqian Wang, Shujuan Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Angiogenesis Receptor expression Single-nucleotide polymorphism Malignancy medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Neoplasms Genetics medicine Animals Humans Genetic Predisposition to Disease Receptor Molecular Biology Polymorphism Genetic business.industry Cancer Adrb2 gene General Medicine medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Receptors Adrenergic beta-2 Carcinogenesis business Signal Transduction |
| Zdroj: | Molecular Biology Reports. 48:2741-2749 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients. |
| Databáze: | OpenAIRE |
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