Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)
| Autor: | Laura Sahuquillo Frías, Mercedes González Morales, Alfonso-L Blazquez-Manzanera, Matilde Cháfer Rudilla, Yolanda Pastor Murcia, María C Baamonde Calzada, María L López Yepes, Luis García de Guadiana-Romualdo, Amparo Galán Ortega, Juan Adell Ruiz de León, Jose I Gutiérrez Revilla, María Gloria García Arévalo, Cristina Acevedo Alcaraz, Ruth González Tamayo, Amaia Fernández Uriarte, Álex Larruzea, Luis Vicente Gutiérrez, Josep Miquel Bauça, Álvaro Blasco Barbero, Marina Vera, Jose M Álamo, Paloma Salas Gómez-Pablos, Silvia Sánchez Fdez-Pacheco, Luis Sáenz, Olaia Rodríguez-Fraga, Jorge Férriz Vivancos, Cristina Ruiz Iruela, María-Carmen Lorenzo-Lozano, Patricia Esteban Torrella, Laura Altimira Queral, Daniel Morell-García, Sara García Muñoz, Eloísa Urrechaga, Natalia Sancho-Rodríguez, Juan A Vílchez, Patricia de la Hera Cagigal, Alfonso Pérez Martínez, José Pedregosa Díaz, María Arnaldos Carrillo, Laura Jiménez Añón, Jose Manuel Egea-Caparrós, María Núñez Gárate, Vicente Aguadero, Vicente Ferrer Díaz de Brito Fernández, María C Zamorano Andrés, Ana María Lourdes Padilla Jiménez, Iria Cebreiros López, Elisa Nuez-Zaragoza, Irene Gutiérrez Garcia, Clara Esparza Del Valle, Martí Vila Pérez, Magdalena Canalda Campás, Cristian Morales-Indiano, María A Juncos Tobarra, Alicia Ruiz Ripa, Ana M Hernando Holgado, Isabel Vírseda Chamorro, Aurelio Pons Castillo, María José Alcaide Martín |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Clinical Biochemistry 030204 cardiovascular system & hematology laboratory tests 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine prognosis Medicine Humans 030212 general & internal medicine Hospital Mortality Young adult Aged Retrospective Studies Aged 80 and over multicenter study business.industry Proportional hazards model SARS-CoV-2 adjustment Hazard ratio COVID-19 Retrospective cohort study General Medicine Emergency department Middle Aged Confidence interval Hospitalization Spain Population study Observational study Original Article Female business Emergency Service Hospital Research Article |
| Zdroj: | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname SCAND J CLIN LAB INV r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Scandinavian Journal of Clinical and Laboratory Investigation article-version (VoR) Version of Record r-FISABIO. Repositorio Institucional de Producción Científica |
| ISSN: | 0036-5513 |
| Popis: | Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome. |
| Databáze: | OpenAIRE |
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