Monoclonal Antibody to the Receptor for Murine Coronavirus MHV-A59 Inhibits Viral Replication In Vivo
| Autor: | Deborah F. Winograd, Kathryn V. Holmes, Christine B. Cardellichio, Mark de Souza, Abigail L. Smith, Stephen W. Barthold |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.drug_class
viruses medicine.medical_treatment Concise Communications Biology Virus Replication Monoclonal antibody medicine.disease_cause Mice Mouse hepatitis virus medicine Animals Immunology and Allergy Coronavirus Murine hepatitis virus Antibodies Monoclonal Brain virus diseases Immunotherapy biology.organism_classification Virology Vaccination Infectious Diseases Liver Viral replication Hepatitis Viral Animal biology.protein Receptors Virus Viral disease Antibody |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/163.4.879 |
| Popis: | Because many strains of mouse hepatitis virus (MHV) infect laboratory mice, no effective vaccine has yet been developed. An alternative approach to control MHV disease is the use of a host cell receptor-targeted ligand. Toaddress the potential usefulness of this approach, a monoclonal antibody directed against the host cell receptor for the coronavirus MHV-A59 was administered to infant mice that were then challenged oronasally with 104 intracerebral infant mouse median lethal doses of MHV-A59. Antibody treatment of virus-challenged mice resulted in lower proportions of mice with MHV-A59 in target organs and markedly reduced viral titers in these organs compared with mock-treated infected mice. Some antibody-treated infected mice survived for 7 days after viral challenge, whereas no mock-treated, infected mice survived beyond day 3 after viral inoculation. These results support a receptor-targeted approach to intervention in coronavirus disease. |
| Databáze: | OpenAIRE |
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