Elevated homocysteine is associated with poorer self-perceived physical health in older men: The Health in Men Study
Autor: | Yuen Y. E. Wong, Osvaldo P. Almeida, Graeme J. Hankey, Kieran McCaul, Leon Flicker, Bu B. Yeap, Frank M. van Bockxmeer |
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Rok vydání: | 2012 |
Předmět: |
Male
Gerontology Genotype Homocysteine Health Status Hyperhomocysteinemia General Biochemistry Genetics and Molecular Biology Odds chemistry.chemical_compound Quality of life Polymorphism (computer science) Confidence Intervals Humans Medicine Methylenetetrahydrofolate Reductase (NADPH2) Aged Aged 80 and over Polymorphism Genetic biology business.industry Obstetrics and Gynecology Physical health chemistry Quartile Methylenetetrahydrofolate reductase Cohort Quality of Life biology.protein Regression Analysis Perception business |
Zdroj: | Maturitas. 73:158-163 |
ISSN: | 0378-5122 |
DOI: | 10.1016/j.maturitas.2012.06.007 |
Popis: | To determine the relationship between high total homocysteine (tHcy) and self-perceived physical health, by investigating the associations between tHcy, the methylenetetrahydrofolate reductase (MTHFR) 677T polymorphism and physical health-related quality of life (HRQOL).We conducted a cross-sectional study using a cohort of 4248 community-dwelling men aged 70-88 years.In addition to clinical determinants of physical health, tHcy was measured by immunoassay, the MTHFR 677T polymorphism was detected by a polymerase chain reaction (PCR)-based method, and physical HRQOL were assessed with the SF-36 Health Survey.In multiple regression analyses, the odds of being in the lowest quartile of the physical component summary (PCS) scores (i.e.35) was 1.47 (95% CI 1.21-1.78) for men with high tHcy (≥15 μmol/l), after adjusting for age, smoking, history of hazardous alcohol use, polypharmacy, prevalent falls and weighted Charlson co-morbidity index. When history of hypertension, heart disease, stroke, arthritis and osteoporosis were included in place of the Charlson's index, the result was unchanged (OR 1.45, 95% CI 1.20-1.75). Men with the MTHFR TT homozygosity had significantly higher tHcy concentration than those with the CC genotype (mean difference of 1.38 μmol/l, 95% CI 0.77-1.99). However, there was no apparent association between the MTHFR polymorphism and PCS.Elevated tHcy is associated with poorer self-perceived physical health in community-dwelling older men. The results of this study support further longitudinal investigations to assess this relationship prospectively. |
Databáze: | OpenAIRE |
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