Study of a pingyangmycin delivery system: Zein/Zein-SAIB in situ gels
| Autor: | Pingtian Ding, Jing Wei, Jian Shi, Zi-bin Gao, Li Zhang, Dawei Chen, Shuqin Yuan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
In situ
Sucrose Stereochemistry Hydrochloride Zein Pharmaceutical Science Microscopy Atomic Force Dosage form Excipients chemistry.chemical_compound Bleomycin Drug Delivery Systems In vivo Animals Pingyangmycin Particle Size Sucrose acetate isobutyrate Chromatography Antibiotics Antineoplastic Viscosity chemistry Drug delivery Microscopy Electron Scanning Delivery system Rabbits Gels |
| Zdroj: | International journal of pharmaceutics. 328(1) |
| ISSN: | 0378-5173 |
| Popis: | Venous malformations (VM) are common vascular abnormality, and their management remains difficult. Pingyangmycin hydrochloride (PYM) is a useful sclerosant to treat venous malformations. This study was aimed to evaluate the effect of a new drug delivery system, PYM-loaded Zein/Zein–sucrose acetate isobutyrate (SAIB) in situ gels, in gelling and extending the local release of PYM. It was demonstrated that in vitro and in vivo release of PYM from the in situ gels could be extended up to 7 and 4 days, respectively. SAIB could significantly cut down the initial burst of PYM from the in situ gels (P < 0.05). The possible gel forming and drug release mechanisms were described according to the morphology analysis by atomic force microscopy (AFM), optical microscopy and SEM. The gel forming efficacy and the viscosity of in situ gel solutions were satisfying. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect