Improved Normothermic Machine Perfusion after Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys
| Autor: | Søren Krag, Stine Lohmann, Bente Jespersen, Stina J M Lignell, Cyril Moers, Kate R Lewis, Merel B F Pool, Henri G. D. Leuvenink, Rutger J. Ploeg, Kaithlyn M Rozenberg, Bjarne Kuno Møller, Ulla Møldrup, Anna Krarup Keller, Carla C. Baan, Marco Eijken, James P. Hunter |
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| Přispěvatelé: | Groningen Institute for Organ Transplantation (GIOT), Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Transplantation
Kidney Machine perfusion business.industry lcsh:Surgery Cold storage Renal function Hemodynamics lcsh:RD1-811 030230 surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Basic Science Anesthesia Renal blood flow Long period ComputingMethodologies_DOCUMENTANDTEXTPROCESSING medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Lignell, S, Lohmann, S, Rozenberg, K M, Leuvenink, H G D, Pool, M B F, Lewis, K R, Moers, C, Hunter, J P, Ploeg, R J, Eijken, M, Møldrup, U, Krag, S, Baan, C C, Møller, B K, Keller, A K & Jespersen, B 2021, ' Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys ', Transplantation Direct, vol. 7, no. 2, e653 . https://doi.org/10.1097/TXD.0000000000001108 Transplantation direct, 7(2):e653. LIPPINCOTT WILLIAMS & WILKINS Transplantation Direct, Vol 7, Iss 2, p e653 (2021) Transplantation Direct, 7(2):e653. Wolters Kluwer Health Transplantation Direct |
| ISSN: | 2373-8731 |
| DOI: | 10.1097/TXD.0000000000001108 |
| Popis: | Supplemental Digital Content is available in the text. Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed. Some techniques require further optimization before implementation in full scale transplantation studies. Using a porcine donation after circulatory death kidney model, we investigated whether initial kidney hemodynamics improved during normothermic machine perfusion if this was preceded by a short period of oxygenated hypothermic machine perfusion (oxHMP) rather than static cold storage (SCS). Methods. Kidneys subjected to 75 minutes of warm ischemia were randomly assigned to either SCS (n = 4) or SCS + oxHMP (n = 4), with a total cold storage time of 240 minutes. Cold preservation was followed by 120 minutes of normothermic machine perfusion with continuous measurement of hemodynamic parameters and renal function. Results. oxHMP preserved kidneys maintained significantly lower renal resistance throughout the normothermic machine perfusion period compared to SCS kidneys (P |
| Databáze: | OpenAIRE |
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