Preliminary assessment of anti-α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection
| Autor: | Gustavo Pereira Cardoso-Oliveira, M. G. Finn, Zélia Barbosa de Almeida Coelho, Érika Martins Braga, Alexandre F. Marques, Cor Jesus Fernandes Fontes, Carlos Sanhueza-Chavez, Luiza Carvalho Mourão, Beatriz Carolina Medeiros Rodrigues, Robert Hincapie |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Adult lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Short Communication 030231 tropical medicine Plasmodium vivax lcsh:QR1-502 lcsh:Microbiology 03 medical and health sciences Young Adult 0302 clinical medicine Immune system ABO blood group system parasitic diseases Malaria Vivax Medicine Humans antibodies In patient biology business.industry α-Gal Middle Aged biology.organism_classification medicine.disease Antibodies Anti-Idiotypic Immunoglobulin M Immunoglobulin G Vivax malaria Immunology biology.protein Plasmodium vivax infection Antibody business Malaria |
| Zdroj: | Memórias do Instituto Oswaldo Cruz, Volume: 114, Article number: e190145, Published: 04 JUL 2019 Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 114 |
| Popis: | Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria. |
| Databáze: | OpenAIRE |
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