Evaluation of phytochemical composition, toxicity in Drosophila melanogaster and effects on antibiotics modulation of Plathymenia reticulata Benth extract
| Autor: | Henrique Douglas Melo Coutinho, F.N. Pereira-Júnior, J.C.A. Pinheiro, Fábia F. Campina, Rafael Pereira da Cruz, J. T. Calixto Júnior, N.S. Macedo, E.M. Luna, D.L. Sena Júnior, Janaína Esmeraldo Rocha, Thiago Sampaio de Freitas, Gabriel Venancio Cruz, Maria Amanda Nobre Lisboa, A.M.R. Teixeira, Z.S. Silveira, Maria do Socorro Costa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Plathymenia reticulata
medicine.drug_class Health Toxicology and Mutagenesis Antibiotics 010501 environmental sciences Biology Toxicology 01 natural sciences 03 medical and health sciences 0302 clinical medicine Antibiotic resistance RA1190-1270 medicine Medicinal plants 0105 earth and related environmental sciences Antimicrobian activity Plathymenia Toxicity Traditional medicine Regular Article Fabaceae biology.organism_classification Plant extract visual_art Toxicology. Poisons visual_art.visual_art_medium Bark Antibacterial activity 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports, Vol 8, Iss, Pp 732-739 (2021) Toxicology Reports |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2021.03.020 |
| Popis: | Graphical abstract Hghlights • The HEPrB showed direct antibacterial activity. • The HEPrB showed no bacterial resistance modifying activity. • This negative effect must be due the antioxidant effect of phenolic compounds. Bacterial resistance is interfering with the action of antibiotics for clinical use in treating pathologies. The search for new substances capable of combating this resistance is necessary. An alternative to the search for these substances is in the extract of medicinal plants. Plathymenia reticulata, plant of the Fabaceae family, is a common tree species from the Brazilian cerrado, and is commonly used in areas of environmental degradation. This species is rich in phenolic compounds, such as flavonoids and tannins, compounds that are associated with various biological effects. A hydroethanolic extract from the bark of Plathymenia reticulata (HEPrB) was produced and then tests were carried out to verify the direct antibacterial activity, the modulatory effect of antibiotics for clinical use and their toxicity in Drosophila melanogaster flies. Through the analysis with UPLC, a wide variety of flavonoids contained in the HEPrB was observed. Direct antibacterial activity was observed for the standard strain of Staphylococcus aureus, however, the extract showed antagonistic activity or no significance in relation to the antibiotics tested in this study. As for toxicity, the HEPrB did not show significant damage in the proposed model. The results emphasize care when associating the consumption of teas with treatments with antibiotics for clinical use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|