Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections
| Autor: | K. Karljiković-Rajić, Z. Binenfeld, B. Stankovic |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science chemistry.chemical_element colorimetry 010402 general chemistry 01 natural sciences Chloride Colorimetry (chemical method) Analytical Chemistry Absorbance compleximetry Drug Discovery medicine Spectroscopy Detection limit Chromatography Chemistry 010401 analytical chemistry Molar absorptivity 6. Clean water 0104 chemical sciences Ionic strength Obidoxime Chloride palladium(II) chloride [Obidoxime chloride] Nuclear chemistry medicine.drug Palladium |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis |
| Popis: | It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9–8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ionic strength μ = 0.55 M, is found to be 10 5.3 . The molar absorptivity at 355 nm is 3.16 × 10 4 l mol −1 cm −1 at pH 6.3. Beer's law is obeyed up to 20 μmol l −1 obidoxime chloride concentration. The detection limit of the method is 0.36 μg ml −1 . The relative standard deviation ( n = 10) varies over the range 1.10–2.66%. The proposed method was found to be suitable for the accurate and sensitive analysis of obidoxime chloride in water and injection solutions. |
| Databáze: | OpenAIRE |
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