Intraoperative quantitative functional brain mapping using an RGB camera

Autor: Raphaël Sablong, Laurent Mahieu-Williame, Jacques Guyotat, Charly Caredda, Laure Alston, Michaël Sdika, Bruno Montcel
Přispěvatelé: RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Service de Neurochirurgie D, Hospices Civils de Lyon (HCL), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Paper
intraoperative imaging
Haemodynamic response
Computer science
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
[SDV]Life Sciences [q-bio]
Neuroscience (miscellaneous)
RGB camera
01 natural sciences
Brain mapping
010309 optics
03 medical and health sciences
Functional brain
optical imaging
0302 clinical medicine
Robustness (computer science)
Cortex (anatomy)
0103 physical sciences
medicine
Radiology
Nuclear Medicine and imaging
Radiological and Ultrasound Technology
business.industry
functional brain mapping
RGB camera Paper 19077RR
Pattern recognition
Human brain
Monte-Carlo simulations
Research Papers
medicine.anatomical_structure
RGB color model
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Artificial intelligence
business
hemodynamic response
030217 neurology & neurosurgery
Electrical brain stimulation
Zdroj: Neurophotonics
Neurophotonics, 2019, 6 (04), pp.1. ⟨10.1117/1.NPh.6.4.045015⟩
Neurophotonics, Society of Photo-optical Instrumentation Engineers (SPIE), 2019, 6 (04), pp.1. ⟨10.1117/1.NPh.6.4.045015⟩
ISSN: 2329-423X
2329-4248
Popis: International audience; Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular, new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the computation of hemodynamics-based functional brain maps using an RGB camera and a white light source. We measure the quantitative oxy and deoxyhemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to evaluate the functional brain areas following neuronal activation by physiological stimuli. The results show a good correlation between the computed quantitative functional maps and the brain areas localized by electrical brain stimulation (EBS). We demonstrate that an RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in a robust way the functional areas during neurosurgery and serve as a tool of choice to complement EBS. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Databáze: OpenAIRE
Externí odkaz: