Children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor in Norway from 1974 through 2013: Unexplainable regional differences in survival
| Autor: | Hrvoje Miletic, Terje Nordberg, Snezana Maric, Tom Børge Johannesen, Jana Rydland, Tor Åge Myklebust, Bernt J. Due-Tønnessen, Kristin Smistad Myrmel, Ole Solheim, Anne Grete Bechensteen, Finn Wesenberg, Tore Stokland, Johan Cappelen, Ingrid Torsvik, Paulina Due-Tønnessen, Bård Krossnes, Viggo Moholdt, Tryggve Lundar, Gry Wikran, Bernward Zeller, Petter Brandal, Aleksandra Kepka, Kristin Solem, Einar Stensvold |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Population Gastroenterology Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Supratentorial Primitive Neuroectodermal Tumor Internal medicine medicine Humans Neuroectodermal Tumors Primitive education Cerebellar Neoplasms Child Retrospective Studies Medulloblastoma education.field_of_study business.industry Norway Hazard ratio Infant Newborn Infant Supratentorial Neoplasms Hematology University hospital medicine.disease Combined Modality Therapy Survival Analysis Cancer registry Treatment Outcome Oncology 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Cohort Female business Regional differences 030215 immunology |
| Zdroj: | 66:e27910 Pediatric Blood & Cancer |
| ISSN: | 1545-5009 |
| Popis: | Background: A previous study based on Norwegian Cancer Registry data suggested regional differences in overall survival (OS) after treatment for medulloblastoma (MB) and supratentorial primitive neuroectodermal tumor (CNS-PNET) in Norway. The purpose of the present study was to confirm in an extended cohort whether there were regional differences in outcome or not, and if so try to identify possible explanations. Material and methods: Data from patients aged 0–20 years diagnosed with and treated for MB/CNS-PNET at all four university hospitals in Norway from 1974 to 2013 were collected and compared. Results: Of 266 identified patients, 251 fulfilled inclusion criteria. MB was diagnosed in 200 and CNS-PNET in 51 patients. Five-year OS and event-free survival (EFS) were 59% and 52%, respectively. There was a significant difference in five-year OS and EFS between MB and CNS-PNET patients; 62% versus 47% (P = 0.007) and 57% versus 35% (P < 0.001). In multivariable analysis, two factors were found to significantly contribute to improved five-year OS and EFS, whereas one factor contributed to improved five-year OS only. Gross total resection (GTR) versus non-GTR (hazard ratio [HR] 0.53, P = 0.003; HR 0.46, P < 0.001) and cerebrospinal irradiation (CSI) versus non-CSI (HR 0.24, P < 0.001; HR 0.28, P < 0.001) for both, and treatment outside Oslo University Hospital for OS only (HR 0.64, P = 0.048). Conclusion: Survival was comparable with data from other population-based studies, and the importance of GTR and CSI was confirmed. The cause for regional survival differences could not be identified. |
| Databáze: | OpenAIRE |
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