Trimipramine in the Treatment of Gastric Ulcer
| Autor: | J Myren, K Valnes, Qvigstad T |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.drug_class Placebo Placebo group law.invention Placebos Double-Blind Method Randomized controlled trial Dibenzazepines law Humans Medicine Stomach Ulcer Aged Clinical Trials as Topic business.industry Stomach Gastroenterology Trimipramine Middle Aged digestive system diseases Clinical trial medicine.anatomical_structure Before Bedtime Sedative Anesthesia Drug Evaluation Female business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 13:497-500 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365527809181928 |
| Popis: | Forty patients with endoscopically confirmed gastric ulcers, completed a double-blind study comparing trimipramine with placebo during 4 weeks' treatment. The daily dose of trimipramine was 50 mg given before bedtime. No serious side-effects occurred. After four weeks' treatment 12 of the 20 patients receiving trimipramine had endoscopically completely healed ulcers, while in the placebo group only 4 of the 20 ulcers were healed (P = 0.025). With regard to the patients' complaints, a distinct and statistically significant improvement was also observed in the patients receiving trimipramine (P = 0.025). It is assumed that the previously shown antisecretory effect of the drug, together with the sedative and anti-depressive effect, make trimipramine a valuable drug in the treatment of peptic ulcer disease. |
| Databáze: | OpenAIRE |
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