Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids
Autor: | Praveen Ballabh, Claudia Califano, Maciej Simm, Jaishree Kumari, Alfred N. Krauss, Martin Lesser, Susanna Cunningham-Rundles, Ajey Jain |
---|---|
Rok vydání: | 2004 |
Předmět: |
Male
medicine.medical_specialty Time Factors Neutrophils Anti-Inflammatory Agents CD18 behavioral disciplines and activities Dexamethasone Fluorescence Monocytes Leukocyte Count Antigens CD Internal medicine mental disorders medicine Humans Infant Very Low Birth Weight L-Selectin Bronchopulmonary Dysplasia CD11b Antigen biology Respiratory distress Cell adhesion molecule business.industry Infant Newborn Obstetrics and Gynecology hemic and immune systems General Medicine medicine.disease Flow Cytometry Endocrinology Integrin alpha M Bronchopulmonary dysplasia CD18 Antigens Pediatrics Perinatology and Child Health Immunology biology.protein Arterial blood L-selectin Female Original Article business Biomarkers medicine.drug |
Zdroj: | Archives of disease in childhood. Fetal and neonatal edition. 89(1) |
ISSN: | 1359-2998 |
Popis: | Aims: To study a longitudinal change in the expression of adhesion molecules CD11b, CD18, and CD62L on neutrophils and monocytes in very low birth weight babies who develop respiratory distress syndrome, to compare these levels between bronchopulmonary dysplasia (BPD) and non-BPD infants, and to assess the effect of corticosteroid treatment on these adhesion molecules. Methods: Of 40 eligible neonates, 11 neonates were oxygen dependent at 36 weeks (BPD 36 weeks), 16 infants were oxygen dependent at 28 days, but not at 36 weeks (BPD d28), and 13 infants did not develop BPD. Seventeen neonates received a six day course of steroid treatment. Expression of CD11b, CD18, and CD62L was measured on neutrophils and monocytes in arterial blood on days 1, 3, 7, 14, 21, and 28, and before and 2–3 days after initiation of dexamethasone treatment by flow cytometry. Results: CD18 expression on neutrophils and monocytes and CD62L on neutrophils, measured as mean fluorescent intensity, was significantly decreased in BPD neonates compared to non-BPD neonates on days 1–28. Dexamethasone treatment significantly decreased CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18L expression on monocytes. Conclusions: Decreased CD18 expression on neutrophils and monocytes, and decreased CD62L expression on neutrophils, measured as mean fluorescent intensity during the first four weeks of life in micropremies may be risk factors and early predictors of BPD. Dexamethasone use was associated with decreased expression of CD11b, CD18, and CD62L. |
Databáze: | OpenAIRE |
Externí odkaz: |