Adenoid glioblastoma arising in a patient with neurofibromatosis type-1
| Autor: | Tetsuaki Sugimoto, Takao Kodama, Hiroshi Itoh, Shiro Miyata, Shinichiro Wakisaka, Hiroaki Kataoka, Yutaka Akiyama, Shinichi Nakano |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Neurofibromatosis 1 Nausea Vomiting Adenoid Pathology and Forensic Medicine Diagnosis Differential Eosinophilic Glial Fibrillary Acidic Protein medicine Humans Neurofibromatosis neoplasms Glial fibrillary acidic protein biology business.industry Brain Neoplasms S100 Proteins Headache General Medicine medicine.disease Immunohistochemistry Magnetic Resonance Imaging nervous system diseases Basophilic medicine.anatomical_structure biology.protein Female medicine.symptom Differential diagnosis business Glioblastoma |
| Zdroj: | Pathology international. 55(6) |
| ISSN: | 1320-5463 |
| Popis: | An unusual case of glioblastoma with adenoid structures arising in a 30-year-old Japanese woman with neurofibromatosis type-1 (NF1) is reported. The patient was admitted to University of Miyazaki Hospital, complaining of headache, nausea and vomiting. From the neuroradiological findings the patient was diagnosed as having glioblastoma, and the tumor was surgically resected. Histologically, the tumor consisted mainly of dark basophilic cells showing prominent tubular or glandular structures surrounded by large eosinophilic cells, in addition to the typical glioblastoma features in the periphery of the tumor. Both cells showed strong stainability with glial fibrillary acidic protein (GFAP) and S-100 protein immunohistochemically, so that the tumor was classified as adenoid glioblastoma. Several cases of glioblastoma have been reported to reveal the adenoid or epithelioid differentiation. The patients with NF1 are prone to develop malignant tumors including glioblastoma, but no cases representing adenoid glioblastoma associated with NF1 have been reported. This report is considered to be the first case of adenoid glioblastoma arising in a patient with NF1. The recognition of the existence of epithelial features of glioblastoma would be important in differential diagnosis of epithelioid tumors of the brain including metastatic carcinomas. |
| Databáze: | OpenAIRE |
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