KCNQ1OT1: An Oncogenic Long Noncoding RNA
| Autor: | Suryakant K. Niture, Deepak Kumar, Qi Qi, Patrice Cagle |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Carcinogenesis
Review Biology Microbiology Biochemistry Metastasis medicine Humans competing endogenous RNA long noncoding RNA Molecular Biology Cell Proliferation human cancers KCNQ1OT1 Competing endogenous RNA Cancer Myeloid leukemia Oncogenes Cell cycle medicine.disease QR1-502 Long non-coding RNA Antisense RNA Gene Expression Regulation Neoplastic Cancer research RNA Long Noncoding |
| Zdroj: | Biomolecules Biomolecules, Vol 11, Iss 1602, p 1602 (2021) |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom11111602 |
| Popis: | Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) encodes a lncRNA from the opposite strand of KCNQ1 in the CDKN1C/KCNQ1OT1 cluster that is reported to play a vital role in the development and progression of cancer. KCNQ1OT1 regulates cancer cell proliferation, cell cycle, migration and invasion, metastasis, glucose metabolism, and immune evasion. The aberrant expression of KCNQ1OT1 in cancer patients is associated with poor prognosis and decreased survival. This review summarizes recent literature related to the biological functions and molecular mechanisms of KCNQ1OT1 in various human cancers, including colorectal, bladder, breast, oral, melanoma, osteosarcoma, lung, glioma, ovarian, liver, acute myeloid leukemia, prostate, and gastric. We also discuss the role of KCNQ1OT1 as a promising diagnostic biomarker and a novel therapeutic target in human cancers. |
| Databáze: | OpenAIRE |
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