Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Autor: Benjamin Zollinger, Petra Susan Hüppi, Lara Lordier, Laura Gui, François Lazeyras, Alexandra Adam-Darque, Nicolas Kunz, Matteo Bastiani, Joana Sa de Almeida, Cristina Borradori-Tolsa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Emotions
Infant
Premature
Diseases
Audiology
distortion correction
0302 clinical medicine
Neural Pathways
Medicine
Infant
Very Low Birth Weight
Human brain development
CIBM-AIT
Sensory stimulation therapy
ddc:618
05 social sciences
Extreme capsule
Magnetic Resonance Imaging
White Matter
medicine.anatomical_structure
Diffusion tensor imaging
Neurology
Auditory Perception
Female
fractional anisotropy
Infant
Premature
Tractography
medicine.medical_specialty
External capsule
white-matter changes
low-birth-weight
Cognitive Neuroscience
Uncinate fasciculus
ddc:616.0757
Emotional processing
050105 experimental psychology
Music intervention
lcsh:RC321-571
White matter
03 medical and health sciences
Neuroimaging
Neuroplasticity
mr-images
impaired recognition
Humans
0501 psychology and cognitive sciences
human brain
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
human fetal
business.industry
Infant
Newborn
Infant
Preterm birth
probabilistic diffusion tractography
central-nervous-system
business
030217 neurology & neurosurgery
Music
Zdroj: NeuroImage, Vol 207, Iss, Pp 116391-(2020)
NeuroImage, Vol. 207 (2020) P. 116391
ISSN: 1095-9572
1053-8119
Popis: Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to later neurodevelopmental impairments. Musicotherapy in the NICU environment has been proposed to promote sensory stimulation, relevant for activity-dependent brain plasticity, but its impact on brain structural maturation is unknown. Neuroimaging studies have demonstrated that music listening triggers neural substrates implied in socio-emotional processing and, thus, it might influence networks formed early in development and known to be affected by prematurity. Using multi-modal MRI, we aimed to evaluate the impact of a specially composed music intervention during NICU stay on preterm infant's brain structure maturation. 30 preterm newborns (out of which 15 were exposed to music during NICU stay and 15 without music intervention) and 15 full-term newborns underwent an MRI examination at term-equivalent age, comprising diffusion tensor imaging (DTI), used to evaluate white matter maturation using both region-of-interest and seed-based tractography approaches, as well as a T2-weighted image, used to perform amygdala volumetric analysis. Overall, WM microstructural maturity measured through DTI metrics was reduced in preterm infants receiving the standard-of-care in comparison to full-term newborns, whereas preterm infants exposed to the music intervention demonstrated significantly improved white matter maturation in acoustic radiations, external capsule/ claustrum/extreme capsule and uncinate fasciculus, as well as larger amygdala volumes, in comparison to preterm infants with standard-of-care. These results suggest a structural maturational effect of the proposed music intervention on premature infants' auditory and emotional processing neural pathways during a key period of brain development.
Databáze: OpenAIRE
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