Activation of Lymphocytes in the Pulmonary Inflammatory Response to Silica
| Autor: | Wei Li, Rakesh K. Kumar, Roslynn O'grady |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Interleukin 2
medicine.medical_specialty T-Lymphocytes Immunology Inflammation Biology Lymphocyte Activation Leukocyte Count Mice Immune system Internal medicine Parenchyma medicine Animals Fibroblast Lung Titanium Lymphokines Mice Inbred BALB C DNA synthesis Receptors Interleukin-2 DNA General Medicine T lymphocyte Fibroblasts respiratory system Silicon Dioxide Endocrinology medicine.anatomical_structure Female Collagen medicine.symptom medicine.drug |
| Zdroj: | Immunological Investigations. 19:363-372 |
| ISSN: | 1532-4311 0882-0139 |
| Popis: | Lymphocytes were separated from the parenchymal lung tissue of mice administered either silica or titanium dioxide particles by intratracheal injection. There was an approximately 10-fold increase in the number of T-lymphocytes recovered from silica-treated animals at 2 weeks after injection. This was accompanied by an increase in the percentage of separated cells expressing the interleukin-2 receptor and by enhanced spontaneous DNA synthesis in serum-free culture. No such changes were demonstrable in cells obtained from animals administered titanium dioxide. These results confirm that an influx of T-lymphocytes occurs as part of the early pulmonary inflammatory response to silica particles. Furthermore, lymphocytes in the lung are functionally activated by at least two criteria. Activated T-lymphocytes may play a role in the induction of fibroblast proliferation and collagen synthesis that occurs in silicotic lung disease. |
| Databáze: | OpenAIRE |
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