Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia
| Autor: | Serena Xodo, Sabina Cauci, Giuseppe Toffoli, Erika Cecchin, Giovanni Chiriaco, Carlo Trombetta, Giuseppe Stinco |
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| Přispěvatelé: | Cauci, Sabina, Chiriacò, Giovanni, Cecchin, Erika, Toffoli, Giuseppe, Xodo, Serena, Stinco, Giuseppe, Trombetta, Carlo |
| Rok vydání: | 2016 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Loss of Libido lcsh:Medicine Gastroenterology CAG polymorphism PFS Post-Finasteride Syndrome chemistry.chemical_compound Behavioral Neuroscience 0302 clinical medicine Endocrinology Basic Science loss of libido Erectile Dysfunction androgen receptor finasteride safety Medicine Finasteride Side Effect Young male Original Research 030219 obstetrics & reproductive medicine 5alpha-reductase inhibitor post-finasteride syndrome male pattern hair loss AGA GGN polymorphism erectile dysfunction sexual dysfunction finasteride side effects lcsh:Other systems of medicine Pathophysiology Psychiatry and Mental health Androgen Receptor Finasteride Androgenic Alopecia medicine.symptom Psychology Finasteride Safety Long lasting medicine.medical_specialty Sexual Dysfunction Urology 030209 endocrinology & metabolism Dermatology GGN Polymorphism 03 medical and health sciences Internal medicine Adverse effect Gene business.industry lcsh:R 5α-Reductase Inhibitor medicine.disease CAG Polymorphism Finasteride Side Effects Male Pattern Hair Loss Reproductive Medicine 2708 lcsh:RZ201-999 Discontinuation Androgen receptor Erectile dysfunction Sexual dysfunction chemistry business Male Pattern Hair Lo |
| Zdroj: | Sexual Medicine, Vol 5, Iss 1, Pp e61-e71 (2017) Sexual Medicine |
| ISSN: | 2050-1161 |
| DOI: | 10.1016/j.esxm.2016.11.001 |
| Popis: | Introduction Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). Aim To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. Methods AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). Main Outcome Measures Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS). (CAG)n and (GGN)n repeats were categorized as short ([CAG]9–19, [GGN]23). Results Median age was 32 years, duration of finasteride use was 360 days, and time from finasteride discontinuation was 1,053 days. We observed several frequency differences in symptoms according to (CAG)n and (GGN)n repeat numbers. Three AMS items were worse for medium (GGN)23 than for long (GGN)>23 carriers and one item was worse for short (GGN)2 kg), increased skin dryness, and onset of symptoms after finasteride use. Conclusion This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR. This study showed a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Further studies are necessary to investigate the PFS pathophysiology using a precision medicine approach. |
| Databáze: | OpenAIRE |
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