Potential of fosfomycin in treating multidrug‐resistant infections in children
| Autor: | Phoebe C M Williams |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Antibiotics Carbapenem-resistant enterobacteriaceae Fosfomycin 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Multiple Bacterial 030225 pediatrics medicine Humans 030212 general & internal medicine Child Intensive care medicine Neonatal sepsis business.industry Infant Newborn biochemical phenomena metabolism and nutrition medicine.disease Antimicrobial Anti-Bacterial Agents Clinical trial Multiple drug resistance Pediatrics Perinatology and Child Health business medicine.drug |
| Zdroj: | Journal of Paediatrics and Child Health. 56:864-872 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1111/jpc.14883 |
| Popis: | In an era of increasing antimicrobial resistance, there are limited treatment options available to treat multidrug-resistant organisms in paediatric patients. Fosfomycin is an antibiotic defined as 'critically important' by The World Health Organization due to its potential efficacy against multidrug-resistant bacteria and is increasingly cited in the international literature as a promising antimicrobial for combating sepsis in an era of increasing antimicrobial resistance. With broad-spectrum cover that includes both Gram-positive and Gram-negative organisms and both parenteral and oral formulations available, fosfomycin provides a promising treatment option for paediatric patients. This review summarises fosfomycin's spectrum of activity, published efficacy in paediatric patients, safety considerations and pharmacokinetic data, as well as identifying current clinical trials delineating pharmacokinetic parameters and safety parameters in neonatal sepsis which will provide further information regarding the use of fosfomycin in neonatal and paediatric infections. Limitations regarding the current standards for fosfomycin susceptibility definitions, variations in dosing regimens and the potential mechanisms for resistance are also discussed. |
| Databáze: | OpenAIRE |
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