Study of mirtazapine antidepressant effects in rats
| Autor: | Anna Raone, Alessandro Tagliamonte, Anna Cassanelli, Riccardo Rauggi, Carla Gambarana |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Pain Threshold medicine.medical_specialty Time Factors medicine.drug_class Stress exposure Mirtazapine Receptors Cell Surface Mianserin Pharmacology Motor Activity beta-adrenergic receptors Drug Administration Schedule Rats Sprague-Dawley stress appetitive behavior escape deficit Escape Reaction Internal medicine medicine Animals Pharmacology (medical) Chronic stress Drug Interactions Depressive symptoms Pain Measurement Analysis of Variance Depression Receptor antagonist Animal models 5-HT1A receptors Antidepressive Agents Rats Psychiatry and Mental health Disease Models Animal Endocrinology Acute exposure 5-HT1A receptor Antidepressant Psychology medicine.drug |
| Zdroj: | The international journal of neuropsychopharmacology. 8(3) |
| ISSN: | 1461-1457 |
| Popis: | Mirtazapine is a widely used antidepressant and the aim of this study was to further investigate its antidepressant activity in rats. Thus, the efficacy of long-term mirtazapine treatment was assessed in three models of depressive symptoms induced by stress exposure: the acute escape deficit, the chronic escape deficit, and the stress-induced disruption of the acquisition of an appetitive behaviour sustained by a palatable food (vanilla sugar). Administration of mirtazapine for 2 wk prevented the escape deficit development induced by acute exposure to unavoidable stress. This protective effect was antagonized by the administration of a beta-adrenergic or a 5-HT1A receptor antagonist just before stress exposure; that is, mirtazapine effect was dependent on functional beta-adrenergic and 5-HT1A receptor systems. Repeated stress exposure indefinitely prolongs the condition of escape deficit and a 40-d mirtazapine treatment reversed this model of chronic escape deficit. In a Y-maze satiated rats learn to choose the arm baited with vanilla sugar, and exposure to stress during Y-maze training prevents this learning. Repeated mirtazapine administration completely antagonized the disrupting effect of chronic stress on the acquisition of this instrumental behaviour. We consider these effects to be crucial in the definition of antidepressant activity. |
| Databáze: | OpenAIRE |
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