Yogurt Containing the ProbacteriaLactobacillus acidophilusCombined with Natural Antioxidants Mitigates Doxorubicin-Induced Cardiomyopathy in Rats
| Autor: | Amr El-Karef, Nashwa M Abu-Elsaad, Tarek M. Ibrahim, Ahmed G. Abd Elhameed |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Carbazoles Cardiomyopathy Medicine (miscellaneous) Green tea extract Antioxidants Camellia sinensis Propanolamines Rats Sprague-Dawley chemistry.chemical_compound Lactobacillus acidophilus Atrial natriuretic peptide Functional Food Malondialdehyde Internal medicine Animals Medicine Nutrition and Dietetics business.industry Cholesterol Angiotensin II Myocardium Probiotics Heart Yogurt medicine.disease Daucus carota Surgery Oxidative Stress Endocrinology chemistry Doxorubicin Heart failure Cytokines Carvedilol Lipid Peroxidation Cardiomyopathies business Atrial Natriuretic Factor |
| Zdroj: | Journal of Medicinal Food. 18:950-959 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2014.0104 |
| Popis: | Probiotics and antioxidants have a definite improving effect in cardiovascular diseases. This study aims at mitigating doxorubicin toxicity on cardiac function through consuming a functional food. Five groups of adult male Sprague-Dawley rats were used along 22 weeks. Group I received 30 g/kg/day food enriched with yogurt, green tea extract, and carrots (80, 0.84, and 100 g/kg diet, respectively) from the first week, group II received carvedilol 30 mg/kg/day orally from week 17, group III received both carvedilol and tested food, and groups IV and V were +ve and -ve control groups, respectively. In week 17, cardiomyopathy was induced by i.p. injection of 2.5 mg/kg doxorubicin every 48 h for 2 weeks. Histopathological and electrophysiological examinations and biochemical analysis were done. Lipid peroxidation, antioxidant effect, heart failure compensatory mediators, and proinflammatory cytokines were assessed. Tested food normalized time between the start of Q wave and the end of T wave on electrocardiogram (QT interval) and heart rate compared to the doxorubicin group (P |
| Databáze: | OpenAIRE |
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