Dominant clade‐featured SARS‐CoV‐2 co‐occurring mutations reveal plausible epistasis: An in silico based hypothetical model
| Autor: | A. S. M. Rubayet Ul Alam, Shafi Mahmud, M. Anwar Hossain, Ovinu Kibria Islam, Hassan M. Al-Emran, Shazid Hasan, Keith A. Crandall, Iqbal Kabir Jahid, Mir Raihanul Islam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Translational efficiency
In silico viruses Mutant Biology medicine.disease_cause SARS‐CoV‐2 COVID‐19 Virology medicine Humans Prospective Studies Research Articles Retrospective Studies Genetics Mutation SARS-CoV-2 clades RNA COVID-19 Epistasis Genetic RNA-Dependent RNA Polymerase Phenotype co‐occurring mutations fitness Molecular Docking Simulation virulence infection paradox Infectious Diseases Viral replication Spike Glycoprotein Coronavirus Epistasis Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has evolved into eight fundamental clades with four of these clades (G, GH, GR, and GV) globally prevalent in 2020. To explain plausible epistatic effects of the signature co‐occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and dynamics analyses showed the higher infectiousness of a spike mutant through more favorable binding of G614 with the elastase‐2. RdRp mutation p.P323L significantly increased genome‐wide mutations (p Highlights Most dominant spike mutation favors elastase‐2 binding.The polymerase mutant (P323L) virus may speed up replication that corresponds to higher mutations.ORF3a viroporin substitution (Q57H) decreases ion permeability.N protein mutation (RG203‐204KR) can increase nucleocapsid stability and help evade immunity.Co‐occurring mutations might modulate viral replication and transmission fitness through epistasis. |
| Databáze: | OpenAIRE |
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