Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936
| Autor: | Ian J. Deary, Adele M. Taylor, Matthew H. Iveson, Sarah E. Harris, Andrew M. McIntosh |
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| Rok vydání: | 2021 |
| Předmět: |
Apolipoprotein E
0303 health sciences education.field_of_study medicine.medical_specialty business.industry Population Cognition Social class 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Epidemiology Life course approach Medicine Allele education business 030217 neurology & neurosurgery Applied Psychology Depression (differential diagnoses) 030304 developmental biology Demography |
| Zdroj: | Iveson, M H, Taylor, A, Harris, S E, Deary, I J & Mcintosh, A M 2021, ' Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936 ', Psychological Medicine, pp. 1-9 . https://doi.org/10.1017/S0033291721000623 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291721000623 |
| Popis: | BackgroundPrevious results have been mixed regarding the role of the apolipoprotein E e4 (APOE e4) allele in later-life depression: some studies note that carriers experience greater symptoms and increased risk while others find no such association. However, there are few prospective, population-based studies of the APOE e4-depression association and fewer that examine depressive symptom trajectory and depression risk longitudinally. We examined the association between APOE e4 allele status and longitudinal change in depressive symptoms and depression risk in later-life, over a 12-year follow-up period.MethodsWe used data from 690 participants of the Lothian Birth Cohort 1936 who took part in the Scottish Mental Survey 1947 (aged 11) and were followed-up in later-life over five waves from 2004 to 2019 (aged 70–82). We used APOE e4 allele status to predict longitudinal change in depressive symptom scores and risk of depression (defined by a symptom score threshold or use of depression-related medication). Models were adjusted for sex, childhood cognitive ability, childhood social class, education, adult social class, smoking status and functional limitations at baseline.ResultsDepressive symptom scores increased with age. Once adjusted for covariates, APOE e4 allele status did not significantly predict symptom score trajectories or depression risk. Greater functional limitations at baseline significantly predicted poorer symptom score trajectories and increased depression risk (defined by medications). APOE e4 allele status did not significantly moderate the contribution of sex, education or functional limitations.ConclusionsThere was no evidence that APOE e4 carriers experience an increased risk for later-life depression. |
| Databáze: | OpenAIRE |
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