Novel therapeutic strategies for Alzheimer's disease: Implications from cell-based therapy and nanotherapy
| Autor: | Hossein Derakhshankhah, Willis Collins Akeyo Muganda, Mareike Müller, Zhila Izadi, Mohammad Raoufi, Samira Jafari, John F. Presley, Sajad Sarvari, Mojtaba Falahati, Faezeh Moakedi, Majid Sharifi, Soraya Sajadimajd |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biomedical Engineering
Cell- and Tissue-Based Therapy Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Disease Neuroprotection Cell therapy 03 medical and health sciences Alzheimer Disease Medicine Elderly people Animals Humans General Materials Science 030304 developmental biology 0303 health sciences business.industry Cognition Neurodegenerative Diseases 021001 nanoscience & nanotechnology Molecular Medicine Stem cell 0210 nano-technology business Neuroscience Cell based |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 24 |
| ISSN: | 1549-9642 |
| Popis: | Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which leads to progressive dysfunction of cognition, memory and learning in elderly people. Common therapeutic agents are not only inadequate to suppress the progression of AD pathogenesis but also produce deleterious side effects; hence, development of alternative therapies is required to specifically suppress complications of AD. The current review provides a commentary on conventional as well as novel therapeutic approaches with an emphasis on stem cell and nano-based therapies for improvement and management of AD pathogenesis. According to our overview of the current literature, AD is a multi-factorial disorder with various pathogenic trajectories; hence, a multifunctional strategy to create effective neuroprotective agents is required to treat this disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect