Long-Term Consequences of Complex Living Renal Donation: Is It Safe?
| Autor: | S. Thukral, A. Mazumdar, D.S. Ray |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty 030232 urology & nephrology Renal function India 030230 surgery Kidney Nephrectomy Cohort Studies 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Living Donors Humans Obesity Aged Retrospective Studies Transplantation business.industry Age Factors Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Blood pressure Donation Cohort Albuminuria Surgery Female Kidney Diseases medicine.symptom business Body mass index |
| Zdroj: | Transplantation proceedings. 50(10) |
| ISSN: | 1873-2623 |
| Popis: | Introduction As there is a paucity of literature regarding the long-term outcomes of complex living donors, we conducted this study to assess the effect of kidney donation on the complex living kidney donor. Materials and Methods This retrospective study was conducted in Narayan Health Hospital, Kolkata, Eastern India. The cohort consisted of complex living kidney donors who donated kidneys between the years 2007 and 2012. All donors were 60 years old or older, or were younger than 60 years and had comorbidities like hypertension and obesity. After a minimum follow-up of 5 years, all donors underwent evaluation. Data pertaining to hypertension, new-onset diabetes, body mass index (BMI), estimated glomerular filtration rate (eGFR) and albuminuria, and cardiac events were compared from the time of donation till 5 years post-transplant. Results and Discussion We found a statistically significant increase in blood pressure, number of antihypertensives used, and mean BMI at follow-up. Diabetes mellitus was developed in 22.3% of donors. The mean GFR also decreased significantly at follow-up. There were 42 elderly donors (≥60 years) and 23 ≤ 59 years of age. There was a significant fall of eGFR in both groups, but the percentage fall was similar in both groups. A significant percentage of donors developed proteinuria, the majority being hypertensives. Conclusion Procurement of kidneys from marginal donors should be done cautiously, and donors should be assessed for morbidity and mortality in the future, as we found a statistically significant deterioration in renal function, blood pressure, and BMI over long-term follow-up. |
| Databáze: | OpenAIRE |
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