Impact of FDG-PET/MRI Image Fusion on the Detection of Pancreatic Cancer
Autor: | E. Lopez Hänninen, I. Koch, Bertram Wiedenmann, Roland Felix, Timm Denecke, Holger Amthauer, Michail Plotkin, Michael Böhmig, Jan M. Langrehr, J. Ruf |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Cystadenoma Image processing Adenocarcinoma Fluorodeoxyglucose F18 Predictive Value of Tests Pancreatic cancer Image Processing Computer-Assisted medicine Humans Aged Retrospective Studies Image fusion Hepatology medicine.diagnostic_test business.industry Gastroenterology Magnetic resonance spectroscopic imaging Magnetic resonance imaging Middle Aged equipment and supplies medicine.disease Magnetic Resonance Imaging Pancreatic Neoplasms Positron emission tomography Positron-Emission Tomography Female Lymph Nodes Radiology Tomography Radiopharmaceuticals business Nuclear medicine human activities Preclinical imaging |
Zdroj: | Pancreatology. 6:512-519 |
ISSN: | 1424-3903 |
Popis: | This study assessed the value of image fusion with (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients suspected of having pancreatic cancer.32 patients (12 women, 20 men; age 24-79 years; mean 56.6 years) were included. All patients underwent whole-body FDG-PET examinations and contrast-enhanced MRI. Image fusion used a semiautomatic voxel-based algorithm. Separate reading, side-by-side analysis and evaluation of fused PET/MRI images were performed. Results were correlated to histopathology (n = 30), or clinical follow-up (n = 2).15/32 patients had pancreas cancer and 17/32 patients benign disease. The sensitivity and specificity for cancer detection by FDG-PET were 93 and 41% for visual and 86 and 58% for semiquantitative analysis whereas MRI achieved 100 and 76% respectively. Topographical assignment of PET foci by image fusion was superior to side-by-side analysis in 11/39 (28%) foci (in 8/32 patients). However, a true impact on therapeutic strategy was observed only in 1/8 patients as the presence of multiple metastases, irresectable primaries or medical reasons for inoperability prevented a curative setting.Compared to side-by-side analysis, PET/MRI image fusion improves the anatomical assignment and interpretation of FDG foci. The therapeutic benefit for the patient however is limited in patients with multiple lesions or incurable primaries. |
Databáze: | OpenAIRE |
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