Excellent inter-rater, intra-rater, and telephone-administered reliability of the ALSFRS-R in a multicenter clinical trial

Autor:	Petra Kaufmann, Gilbero Levy, Jacquelina Montes, Richaro Buchsbaum, Alexandra I. Barsdorf, Vanessa Battista, Rachel Arbing, Paul H. Gordon, Hiroshi Mitsumoto, Brvce Levin, John L. P. Thompson
Rok vydání:	2007
Předmět:	medicine.medical_specialty Activities of daily living Intraclass correlation Ubiquinone Coenzymes Severity of Illness Index law.invention Randomized controlled trial Double-Blind Method law Sickness Impact Profile Severity of illness Activities of Daily Living medicine Humans Reliability (statistics) Retrospective Studies business.industry Amyotrophic Lateral Sclerosis Reproducibility of Results Retrospective cohort study General Medicine Vitamins Telephone Clinical trial Inter-rater reliability Neurology Caregivers Physical therapy Neurology (clinical) business
Zdroj:	Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. 8(1)
ISSN:	1748-2968
Popis:	We wished to determine whether the Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) is reliable when used as primary outcome measure in a multicenter clinical trial. To establish inter-rater reliability, we randomly assigned 19 primary raters and 11 back-up raters to score nine amyotrophic lateral sclerosis (ALS) patients using the ALSFRS-R. To assess intra-rater reliability and reliability of telephone administration, we randomly assigned consecutive participants of the Clinical Trial of High Dose Coenzyme Q10 in ALS (QALS) to have in-person ALSFRS-R interviews at both screening and baseline visits (n=41 patients) or to have the ALSFRS-R interview by telephone at screening and in person at the baseline visit (n=27). An intraclass correlation coefficient (ICC) of reliability was calculated using a one-way random effects analysis of variance model. In the inter-rater reliability assessment, the primary raters performed 54 ratings on nine patients with ICC=0.93 (95% CI 0.84-0.98). For back-up raters, 32 ratings on nine patients resulted in ICC=0.93 (95% CI 0.82-0.98). The intra-rater reliability for in-person interviews was ICC = 0.95 (95% CI 0.92-0.98). The reliability of telephone administration compared to in-person interviews was ICC=0.97 (95% CI 0.93-0.98). We conclude that the ALSFRS-R shows excellent inter- and intra-rater reliability, and reliability of telephone administration when used as primary outcome measure in a multicenter ALS trial.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e6343305bc2ccca04b99dfe2543ec0 https://pubmed.ncbi.nlm.nih.gov/17364435 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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