The synthesis and in vitro antibacterial activity of conformationally restricted quinolone antibacterial agents
| Autor: | Pamela K. Donner, Michael D. Tufano, Curt S. Cooper, Daniel T. W. Chu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chemistry
medicine.drug_class Stereochemistry Organic Chemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science Microbial Sensitivity Tests Quinolone Ring (chemistry) Biochemistry In vitro Molecular conformation QUINOLONE ANTIBACTERIALS Quinolone Antibacterial Agents chemistry.chemical_compound Anti-Infective Agents Ciprofloxacin mental disorders Drug Discovery medicine Molecular Medicine Antibacterial activity Molecular Biology Tetrahydrofuran |
| Zdroj: | Bioorganic & Medicinal Chemistry. 4:1307-1315 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/0968-0896(96)00106-x |
| Popis: | Two series of conformationally restricted quinolone antibacterials were synthesized. One series was restricted by formation of a tetrahydrofuran ring between the C-6 position and the C-7 position of the quinolone ring skeleton. The second series achieved conformational rigidity by formation of a tetrahydrofuran ring between the C-7 and the C-8 positions. These compounds were evaluated for their in vitro antibacterial activity. Compounds 19 and 20 were the most active compounds in either series and were about equipotent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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